SOD memetics showing promise as future treatment for inflammatory joint disease

In a disease such as RA where proinflamitory cytokines like TNF-a are being over produced and reactive oxygen species are overwhelming the bodies natural enzymatic defenses.  The use of superoxide dismutase mimetic to supplement the bodies natural defense is showing promises as a possible addition to future therapeutic strategies for fighting inflammatory joint disease.  Along with the article entitled “reactive oxygen species and superoxide dismutase: Role in joint diseases” I also learned of a study by a Italian pharmaceutical company which reported 56% reduction in inflammation and 70% decrease in joint erosion in arthritic rats.   Both studies used the same SOD mimetic M40403.  These reports appear very promising but there still needs to be more testing before human trials can start.